A modular, standalone perfusion bioreactor for robust, monitored and controlled tissue engineering
نویسندگان
چکیده
منابع مشابه
A versatile modular bioreactor platform for Tissue Engineering
Tissue Engineering (TE) bears potential to overcome the persistent shortage of donor organs in transplantation medicine. Additionally, TE products are applied as human test systems in pharmaceutical research to close the gap between animal testing and the administration of drugs to human subjects in clinical trials. However, generating a tissue requires complex culture conditions provided by bi...
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Osteoarthritis is a severe socio-economical disease, for which a suitable treatment modality does not exist. Tissue engineering of cartilage transplants is the most promising method to treat focal cartilage defects. However, current culturing procedures do not yet meet the requirements for clinical implementation. This article presents a novel bioreactor device for the functional tissue enginee...
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Skeletal development is a multistep process that involves the complex interplay of multiple cell types at different stages of development. Besides biochemical and physical cues, oxygen tension also plays a pivotal role in influencing cell fate during skeletal development. At physiological conditions, bone cells generally reside in a relatively oxygenated environment whereas chondrocytes reside ...
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A systematic design of experiments (DOE) approach was used to optimize the perfusion process of a tri-axial bioreactor designed for translational tissue engineering exploiting mechanical stimuli and mechanotransduction. Four controllable design parameters affecting the perfusion process were identified in a cause-effect diagram as potential improvement opportunities. A screening process was use...
متن کاملTissue Engineering Bioreactor
pg. 2) Background (pg. 2-8) Alternative Design Descriptions (pg. 8-11) Final Design (pg. 11-13) References (pg. 13) Appendix A: Product Design Specifications (pg. 13-16)
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ژورنال
عنوان ژورنال: Cytotherapy
سال: 2018
ISSN: 1465-3249
DOI: 10.1016/j.jcyt.2018.02.231